Step 1:
Just got open any folder on your desktop.
Step 2:
Click on tools tab on the top most menu bar.
Step3:
Click on folder options
Step 4:
Now click on view tab in the wizard which opend now.
you will an menu as shown below.

Click on do not cache thumbnail as highlighted in the above picture.
Step6:
Click on ok tab.
that's it you have removed the thumbs.db completely.
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